Chaperone Molecule Holds Promise for Alzheimer’s Treatment

BY Rick Nauert, PHD


A new discovery shows how the body normally cleanses the brain of harmful substances associated with Alzheimer’s disease.

In the study, researchers determined that a molecular chaperone, HspB1, works like a waste management company to collect and detoxify high levels of toxic amyloid beta peptide found in Alzheimer’s disease.

Scientists had known that HspB1 was present in the hallmark plaques that build up between the neurons of Alzheimer’s patients, but its role remained a mystery.

“What we have found is HspB1 is a protective mechanism that tries to get rid of the toxic oligomers or aggregates of amyloid beta that occur in Alzheimer’s,” said Anil G. Cashikar, Ph.D., the corresponding author of the study published in Molecular and Cellular Biology.

Full story at PsychCentral

Son Gives Diabetic Dad Kidney For Father’s Day

By Huffington Post


CBC — A Sussex, N.B., father received an extraordinary gift from his son just in time for Father’s Day — a new kidney.

Arthur Cruickshank, 67, has diabetes and has been undergoing dialysis treatment for years. He lost one of his kidneys three years ago and had seen a rapid decline in his health.

His 39-year-old son Dana decided it was time to offer one of his own kidneys to his father.

“The dialysis was keeping him alive, but he didn’t have any quality of life and he was dying. There’s no doubt about it, he eventually would if he didn’t get a kidney,” Dana said.

Full story at Huffington Post

Understanding Alcohol’s Damaging Effects on the Brain

By ScienceDaily


While alcohol has a wide range of pharmacological effects on the body, the brain is a primary target. However, the molecular mechanisms by which alcohol alters neuronal activity in the brain are poorly understood. Participants in a symposium at the June 2010 annual meeting of the Research Society on Alcoholism in San Antonio, Texas addressed recent findings concerning the interactions of alcohol with prototype brain proteins thought to underlie alcohol actions in the brain.

“Alcohol is the most common drug in the world, has been used by diverse human communities longer than recorded history, yet our understanding of its effects on the brain is limited when compared to other drugs,” said Rebecca J. Howard, a postdoctoral fellow at The University of Texas at Austin Waggoner Center for Alcohol & Addiction Research and corresponding author for this study.

Full story at ScienceDaily

Why Realistic Wisdom Beats Positive Thinking

By Judith Acosta


The other day a client of mine tearfully revealed a childhood filled with fear. Her father was an unpredictable and menacing man who was nearly as big as the front door. She was only a toddler, but she had vivid memories of him hollering as he came into the kitchen, the sweet smell of too much whiskey floating off his skin as he picked up a utensil to beat her mother. Her mother, also a drug user, in rage at her husband, tried to drown her daughter by pouring soap and water down her throat. With mere seconds to go, she was saved by a neighbor who had heard the screaming.

She cried silently for a while and then she asked me: “What did I do wrong?”

At first I heard her as any therapist would. Many, many — too many — children blame themselves for the horror they are born into. Why? Mainly because the people who are hurting them tell them that “It’s all their fault” and because they are children, they simply don’t know any better than to believe them.

Full story at Huffington Post

The Price of Happiness

By Sadhguru


Money is a device that started as a solution beyond the barter system. It was not complicated. It was just a means of exchange; a tool to make life more comfortable. If money is in your pocket, life is more comfortable. But the moment it enters your head, it becomes a perversion. You get identified by it. It becomes who you are. Once you get identified by it, you can never have enough.

There are many wealthy people who become miserable with just a little fluctuation in their net worth. But money is merely a means to an end. Like everything else, money has been created for our well-being. We forget this when we become deeply identified by it.

Instead of just having money to use, we become someone — or something — because of it. Then we begin to compare ourselves to other people instead of enjoying what we have. This becomes a kind of a sickness, where making money is then turned against your own well-being.

Full story at Huffington Post