A new technique for analyzing brain images offers the possibility of using magnetic resonance imaging (MRI) to predict the rate of progression and physical path of many degenerative brain diseases, report scientists at the San Francisco VA Medical Center and the University of California, San Francisco.
The technique, developed by SFVAMC scientists in collaboration with a team led by Bruce Miller, MD, clinical director of the UCSF Memory and Aging Center, also supports mounting evidence that dementias spread through the brain along specific neuronal pathways in the same manner as prion diseases.
The scientists employed new computer modeling techniques to realistically predict the physical progression of Alzheimer’s disease and frontotemporal dementia (FTD) using images of 14 healthy brains. The models were based on whole-brain tractography, an MRI technique that maps the neural pathways, or "communication wires," that connect different areas of the brain. The spread of disease along those pathways, as predicted by the models, closely matched actual MRI images of brain degeneration in 18 Alzheimer’s patients and 18 FTD patients.