Genetics, ethnicity can influence pathway between early drinking and alcohol use disorders

Studies have shown that an early age of drinking initiation (ADI) increases the chance of developing an alcohol use disorder (AUD). There is limited evidence that ADI differs across ethnic groups. This study examined whether the pathway from ADI to AUD symptoms by early adulthood is influenced by two factors: ethnicity and having the alcohol metabolizing gene variant allele, ALDH2*2. This allele produces an inactive enzyme that leads to higher levels of acetaldehyde during alcohol metabolism, which are associated with unpleasant effects after drinking alcohol and a decreased risk for an AUD.

Researchers examined 604 college students recruited from the University of California, San Diego: 214 of Korean ancestry (107 men, 107 women), 200 of European ancestry (106 men, 94 women), and 190 of Chinese ancestry (99 women, 91 men), each with both biological parents having the same heritage. Participants were genotyped for the ALDH2*2 variant allele and completed a self-report assessment.

Full story at Science Daily

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Will Savage

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