A study led by Indiana University on neurochemical changes associated with alcohol addiction found that the neurotransmitter glutamate plays a role in some alcohol cravings.
Alcohol dependence and alcohol use disorders occur in about 30 percent of all Americans, taking a severe toll on people’s lives, as well as on the health care system and economy. Ninety percent of all attempts to cure the dependence or abuse of alcohol result in relapse within four years. These relapses are primarily triggered by sights, sounds and situations associated with past drinking experiences.
“This is the first study to document changes in glutamate levels during exposure to alcohol cues in people with alcohol use disorders and shines a spotlight on glutamate levels as an important target for new therapies to treat the condition,” said Sharlene Newman, a professor in the IU Bloomington College of Arts and Sciences’ Department of Psychological and Brain Sciences.