Opioids without the risk of addiction?

Scientists are working to develop medicines that have the pain-relieving effects of opioids without the high risk of misuse and addiction. Since misuse is linked to the euphoric effects of the drug, investigators led by scientists at NIDA’s intramural labs are studying methadone, a drug used to manage opioid addiction that does not have euphoric effects as strong as many other opioids.

Animal studies show that mu opioid receptors in the brain play a key role in the reinforcing effects of opioid drugs, whereas the neuropeptide galanin counteracts the effects of mu opioid receptors. In a recently published study, investigators found a significant difference in the mechanisms of action between methadone and morphine that is determined by the activation of opioid receptor complexes (heteromers) composed of both mu-opioid receptors and one of the galanin receptor subtypes; differences that are key to their subsequent effects on the brain’s dopamine system.

Full story at drugabuse.org

Published by

Will Savage

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