cocaine use

Chronic cocaine use modifies gene expression

Chronic cocaine use changes gene expression in the hippocampus, according to research in mice recently published in JNeurosci. Chronic drug users learn to associate the drug-taking environment with the drug itself, reinforcing memories that contribute to addiction. These memories are thought to be created by changes in gene expression in the…

In rats that can’t control glutamate, cocaine is less rewarding, staving off relapse

Rats missing a neuroreceptor that controls the release of the neurotransmitter glutamate are less amenable to the rewarding effects of cocaine, increasing their chance of kicking the habit once addicted, researchers from the National Institute on Drug Abuse (NIDA) find. Their work, appearing July 11 in Cell Reports, suggests that the…