Schizophrenia: Restoring brain circuitry to improve symptoms

Researchers pin down the faulty brain circuitry that drives negative symptom severity in schizophrenia and look at noninvasive methods of targeting and “repairing” this breakdown.

Schizophrenia is a mental health condition with characteristic symptoms that include delusions and hallucinations. It also has numerous negative symptoms, such as flat affect (lack of emotional expression), anhedonia, monotone speech, and avoiding social interaction.

According to the National Institute of Mental Health, this condition is among the top 15 causes of disability across the world.

Full story at Medical News Today

Obesity associated with more rapid progression of disability in rheumatoid arthritis patients

In a study of adults with rheumatoid arthritis, those who were severely obese experienced more rapidly progressing disability than patients who were overweight. This was not explained by features of their arthritis, including the amount of inflammation in their joints. In the Arthritis Care & Research study, weight loss after enrollment was also associated with worsening disability, possibly as a sign of frailty.

To examine the effects of obesity in patients with rheumatoid arthritis over time, Joshua Baker, MD, MSCE, of the Perelman School of Medicine at the University of Pennsylvania, and his colleagues examined information on 23,323 patients with rheumatoid arthritis from the National Data Bank of the Rheumatic Diseases and 1697 from the Veterans Affairs RA registry.

Full story at News-Medical.net