Gene expression in an area of the brain linked to addiction is affected differently by repeated binge drinking in males and females, finds a new study published today in Frontiers in Genetics. It reveals for the first time that genes associated with hormone signaling and immune function are affected by repeated binge drinking in female mice, whereas genes associated with nerve signaling are affected in males. These findings have significant implications for the treatment of alcohol use disorder as they emphasize the importance of tailoring effective therapies towards male and female patients.
“We show that repeated binge drinking significantly alters molecular pathways in the nucleus accumbens, a region of the brain linked to addiction. A comparison of activated pathways reveals different responses in each sex, similar to that reported in recent research on male and female mice tested during the withdrawal phase following chronic alcohol intoxication,” says Deborah Finn, a Professor of Behavioral Neuroscience at Oregon Health & Science University and a Research Pharmacologist at the VA Portland Health Care System, USA.
She continues, “These findings are important as they increase our understanding of male and female differences in molecular pathways and networks that can be influenced by repeated binge drinking. This knowledge can help us identify and develop new targeted treatments for alcohol use disorder in males and female patients.”